Biology | |
The Effect of Nutritional Status in the Pathogenesis of Critical Illness Myopathy (CIM) | |
Hannah Ogilvie1  | |
[1] Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, SE-751 85, Sweden; E-Mail: | |
关键词: nutrition; caloric intake; critical illness myopathy; intensive care; | |
DOI : 10.3390/biology3020368 | |
来源: mdpi | |
【 摘 要 】
The muscle wasting and loss of specific force associated with Critical Illness Myopathy (CIM) is, at least in part, due to a preferential loss of the molecular motor protein myosin. This acquired myopathy is common in critically ill immobilized and mechanically ventilated intensive care patients (ICU). There is a growing understanding of the mechanisms underlying CIM, but the role of nutritional factors triggering this serious complication of modern intensive care remains unknown. This study aims at establishing the effect of nutritional status in the pathogenesis of CIM. An experimental ICU model was used where animals are mechanically ventilated, pharmacologically paralysed post-synaptically and extensively monitored for up to 14 days. Due to the complexity of the experimental model, the number of animals included is small. After exposure to this ICU condition, animals develop a phenotype similar to patients with CIM. The results from this study show that the preferential myosin loss, decline in specific force and muscle fiber atrophy did not differ between low
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190025524ZK.pdf | 159KB | download |