Acute and 4-Week Repeated-Dose Oral Toxicity Studies of Cirsium setidens in Rats

Molecules

Jong Seok Lee²  Young-Hyun Kim²  Dan-Bi Kim²  Woo-Suk Bang¹ 

[1] Department of Food and Nutrition, Yeungnam University, Gyeongsan, Gyeongbuk 712-749, Korea;Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea; E-Mails:

关键词: Cirsium setidens;    oral administration;    safety;    toxicity;   

DOI  :  10.3390/molecules19067138

来源: mdpi

【 摘 要 】

Cirsium setidens is a wild perennial plant species found in Korea that may have anti-oxidative, anti-adipogenic, and hepatoprotective activities. However, details of the toxicology of C. setidens remain unknown. This study was performed to evaluate the toxicological effects of an acute administration and 4-week repeated dosing of a C. setidens extract in Sprague-Dawley rats to ensure the safe use of this extract. C. setidens (1250, 2500, and 5000 mg/kg body weight/day) did not induce significant toxicological changes in groups matched by gender with respect to mortality, clinical signs, body weight, urinalysis, ophthalmoscopy, necropsy findings, hematology, and histopathology. Therefore, this study demonstrates that acute administration and 4-week repeated dosing of C. setidens extract orally using this administration protocol is safe.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.