Nine New and Five Known Polyketides Derived from a Deep Sea-Sourced Aspergillus sp. 16-02-1

Marine Drugs

Xiu-Wen Chen²  Chang-Wei Li²  Cheng-Bin Cui²  Wei Hua²  Tian-Jiao Zhu¹ 

[1] Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; E-Mails:;Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China; E-Mails:

关键词: Aspergillus sp. 16-02-1;    fungal strain from deep sea sediment;    aspiketolactonol;    aspilactonol;    aspyronol;    lactone;    epiaspinonediol;    polyketide;    structure;    cytotoxicity;   

DOI  :  10.3390/md12063116

来源: mdpi

【 摘 要 】

Nine new C₉ polyketides, named aspiketolactonol (1), aspilactonols A–F (2–7), aspyronol (9) and epiaspinonediol (11), were isolated together with five known polyketides, (S)-2-(2′-hydroxyethyl)-4-methyl-γ-butyrolactone (8), dihydroaspyrone (10), aspinotriol A (12), aspinotriol B (13) and chaetoquadrin F (14), from the secondary metabolites of an Aspergillus sp. 16-02-1 that was isolated from a deep-sea sediment sample. Structures of the new compounds, including their absolute configurations, were determined by spectroscopic methods, especially the 2D NMR, circular dichroism (CD), Mo₂-induced CD and Mosher’s ¹H NMR analyses. Compound 8 was isolated from natural sources for the first time, and the possible biosynthetic pathways for 1–14 were also proposed and discussed. Compounds 1–14 inhibited human cancer cell lines, K562, HL-60, HeLa and BGC-823, to varying extents.

【 授权许可】

CC BY   
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