An Efficient Synthesis of Pyridoxal Oxime Derivatives under Microwave Irradiation

Molecules

Dajana Gašo-Sokač¹  Valentina Bušić¹  Mario Cetina² 

[1] Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology Osijek, Kuhačeva 20, 31000 Osijek, Croatia; E-Mail:;University of Zagreb, Faculty of Textile Technology, Department of Applied Chemistry, Prilaz baruna Filipovića 28a, 10000 Zagreb, Croatia

关键词: eco-friendly quaternization;    microwave synthesis;    phenacyl bromides;    pyridoxal oxime;   

DOI  :  10.3390/molecules19067610

来源: mdpi

【 摘 要 】

Quaternary salts of pyridoxal oxime have been synthesized by the quaternization of pyridoxal oxime with substituted phenacyl bromides using microwave heating. Microwave-assisted rapid synthesis was done both in solvent (acetone) and under solvent-free conditions. Good to excellent yields (58%–94%) were obtained in acetone in very short reaction times (3–5 min) as well as in the solvent-free procedure (42%–78%) in very short reaction times (7–10 min) too. Effective metodologies for the preparation of pyridoxal oxime quaternary salts, having the advantagies of being eco-friendly, easy to handle, and performed in shorter reactions time are presented. The structure of compound 7, in which a 4-fluorophenacyl moiety is bonded to the pyridinium ring nitrogen atom, was unequivocally confirmed by the single-crystal X-ray diffraction method.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.