Antimicrobial Activity of Resveratrol Analogues

Molecules

Malik Chalal¹  Agnès Klinguer³  Abdelwahad Echairi²  Philippe Meunier⁴  Dominique Vervandier-Fasseur⁴ 

[1] Université de Bourgogne, UMR1347 Agroécologie, ERL CNRS 6300, BP 86510, 21065 Dijon Cedex, France; E-Mail:;Welience, Maison Régionale de L’Innovation, 64 A rue de Sully, CS 77124, 21071 Dijon Cedex, France; E-Mail:;INRA, UMR1347 Agroécologie, ERL CNRS 6300, BP 86510, 21065 Dijon Cedex, France; E-Mail:;Institut de Chimie Moléculaire de l’Université de Bourgogne, ICMUB-UMR CNRS 6302, 9 Avenue Alain Savary, 21000 Dijon, France; E-Mails: Philippe.

关键词: resveratrol;    stilbenes;    grapevine;    downy mildew;    grey mold;    Plasmopara viticola;    Botrytis cinerea;   

DOI  :  10.3390/molecules19067679

来源: mdpi

【 摘 要 】

Stilbenes, especially resveratrol and its derivatives, have become famous for their positive effects on a wide range of medical disorders, as indicated by a huge number of published studies. A less investigated area of research is their antimicrobial properties. A series of 13 trans-resveratrol analogues was synthesized via Wittig or Heck reactions, and their antimicrobial activity assessed on two different grapevine pathogens responsible for severe diseases in the vineyard. The entire series, together with resveratrol, was first evaluated on the zoospore mobility and sporulation level of Plasmopara viticola (the oomycete responsible for downy mildew). Stilbenes displayed a spectrum of activity ranging from low to high. Six of them, including the most active ones, were subsequently tested on the development of Botrytis cinerea (fungus responsible for grey mold). The results obtained allowed us to identify the most active stilbenes against both grapevine pathogens, to compare the antimicrobial activity of the evaluated series of stilbenes, and to discuss the relationship between their chemical structure (number and position of methoxy and hydroxy groups) and antimicrobial activity.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.