Antioxidant and Hepatoprotective Activity of Veronica ciliata Fisch. Extracts Against Carbon Tetrachloride-Induced Liver Injury in Mice

Molecules

Li Yin¹  Lei Wei¹  Rao Fu¹  Lisheng Ding²  Yiran Guo¹  Lin Tang¹ 

[1]College of Life Sciences, Sichuan University, Chengdu 610064, China

[2] E-Mails:

[3]Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China

[4] E-Mail:

关键词: Veronica ciliata Fisch;    antioxidant activity;    hepatoprotective effect;    carbon tetrachloride;    histological examination;   

DOI  :  10.3390/molecules19067223

来源: mdpi

【 摘 要 】

Veronica ciliata Fisch. has been traditionally used in Traditional Chinese Medicine prescriptions due to its curative effects for hepatitis, cholecystitis, rheumatism, and urticaria. The present study was focused on investigating the role of ethyl acetate and aqueous extracts of Veronica ciliata Fisch. Furthermore, in vitro antioxidant activity (scavenging of DPPH, ABTS, superoxide, and nitrite radicals; reducing power; β-carotene bleaching) and the hepatoprotective effect of the ethyl acetate extract by means of CCl₄-induced oxidative stress in mice were investigated. The ethyl acetate extract of Veronica ciliata Fisch. displayed more noteworthy in vitro antioxidant activities than the aqueous extract. Moreover, it significantly prevented the increase in serum T-AOC, ALT, AST and ALP level in acute liver damage induced by CCl₄, decreased the extent of MDA formation in liver and elevated the activities of SOD and GSH in liver. This activity was found to be comparable to that of bifendate. Histopathological observation of the liver was also performed to further support the evidence from the biochemical analysis. The results indicated that strong antioxidant activities and a significant protective effect against acute hepatotoxicity induced by CCl₄ of Veronica ciliata Fisch. were concentrated in the ethyl acetate extract. The results suggested that this activity may be due to free radical-scavenging and antioxidant properties.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.