The Tumor-Associated Marker, PVRL4 (Nectin-4), is the Epithelial Receptor for Morbilliviruses

Viruses

Sebastien Delpeut¹  Ryan S. Noyce¹ 

[1] The Department of Microbiology and Immunology, Dalhousie University, Halifax, B3H 1X5 NS, Canada; E-Mails:

关键词: morbillivirus;    measles virus;    canine distemper virus;    peste des petits ruminants virus;    nectin-4;    PVRL4;    epithelial receptor;    cancer;   

DOI  :  10.3390/v6062268

来源: mdpi

【 摘 要 】

PVRL4 (nectin-4) was recently identified as the epithelial receptor for members of the Morbillivirus genus, including measles virus, canine distemper virus and peste des petits ruminants virus. Here, we describe the role of PVRL4 in morbillivirus pathogenesis and its promising use in cancer therapies. This discovery establishes a new paradigm for the spread of virus from lymphocytes to airway epithelial cells and its subsequent release into the environment. Measles virus vaccine strains have emerged as a promising oncolytic platform for cancer therapy in the last ten years. Given that PVRL4 is a well-knowntumor-associated marker for several adenocarcinoma (lung, breast and ovary), the measles virus could potentially be used to specifically target, infect and destroy cancersexpressing PVRL4.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.