Discriminating Bacteria with Optical Sensors Based on Functionalized Nanoporous Xerogels

Chemosensors

Sabine Crunaire²  Pierre R. Marcoux¹  Khanh-Quyen Ngo²  Jean-Pierre Moy¹  Frຝéric Mallard³ 

[1] Department of Technology for Biology and Health, CEA-LETI-MINATEC, 17 avenue des Martyrs, Grenoble F-38054, France; E-Mails:;CEA, DSM/IRAMIS/NIMBE /Laboratoire Francis Perrin, URA 2453, bât. 522, Gif-sur-Yvette F-91191, France; E-Mails:;bioMérieux SA, 5 rue des Berges, Grenoble F-38000, France; E-Mail:

关键词: Hybrid Materials;    Silica;    Nanoporous Materials;    Biomedical Applications;    Gas sensing;    Direct Optical Transduction;    Absorption spectroscopy;   

DOI  :  10.3390/chemosensors2020171

来源: mdpi

【 摘 要 】

An innovative and low-cost method is proposed for the detection and discrimination of indole-positive pathogen bacteria. The method allows the non-invasive detection of gaseous indole, released by bacteria, with nanoporous colorimetric sensors. The innovation comes from the use of nanoporous matrices doped with 4-(dimethylamino)-cinnamaldehyde, which act as sponges to trap and concentrate the targeted analyte and turn from transparent to dark green, long before the colonies get visible with naked eyes. With such sensors, it was possible to discriminate E. coli from H. alvei, two indole-positive and negative bacteria after seven hours of incubation.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.