Molecules | |
Reduction of the Nitro Group to Amine by Hydroiodic Acid to Synthesize |
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Kazumasa Wakamatsu2  Hitomi Tanaka2  Keisuke Tabuchi2  Makoto Ojika3  Fabio A. Zucca1  Luigi Zecca1  | |
[1] Institute of Biomedical Technologies, National Research Council of Italy, Via Cervi, 93, Segrate, Milano 20090, Italy; E-Mails:;Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi 470-1192, Japan; E-Mails:;Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan; E-Mail: | |
关键词: neuromelanin; aminohydroxyphenylethylamine; aminohydroxyphenylacetic acid; aminohydroxyethylbenzene; Parkinson’s disease; HI reduction; | |
DOI : 10.3390/molecules19068039 | |
来源: mdpi | |
【 摘 要 】
Neuromelanin (NM) is produced in dopaminergic neurons of the substantia nigra (SN) and in noradrenergic neurons of the locus coeruleus (LC). The synthesis of NM in those neurons is a component of brain aging and there is the evidence that this pigment can be involved in the pathogenesis of neurodegenerative diseases such as Parkinson’s disease. NM is believed to derive from the oxidative polymerization of dopamine (DA) or norepinephrine (NE) with the participation of cysteine, dolichols and proteins. However, there are still unknown aspects in the chemical structure of NM from SN (SN-NM) and LC (LC-NM). In this study, we designed a new method to synthesize
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190024977ZK.pdf | 403KB | download |