Synthesis and Fungicidal Activity of Novel Chloro-Containing 1-Aryl-3-oxypyrazoles with an Oximino Ester or Oximino Amide Moiety

Molecules

Yuanyuan Liu³  Yi Li²  Nanqing Chen¹  Kunzhi Lv¹  Chao Zhou³  Xiaohui Xiong² 

[1] College of Science, Nanjing Tech University, Nanjing 211816, China;College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China;Department of Chemical and Pharmaceutical Engineering, Southeast University ChengXian College, Nanjing 210088, China

关键词: synthesis;    fungicidal activity;    chloro-containing 1-aryl-3-oxypyrazoles;    structure-activity relationships;   

DOI  :  10.3390/molecules19068140

来源: mdpi

【 摘 要 】

Six novel chloro-containing 1-aryl-3-oxypyrazoles TMa–TMf with an oximino ester or an oximino amide moiety were prepared by the reaction of 1-aryl-1H-pyrazol-3-ols with benzyl bromide. Their structures were characterized by ¹H-NMR, ¹³C-NMR, IR, MS, and elemental analysis. A preliminary in vitro bioassay indicated that compounds TMa, TMe and TMf displayed excellent fungicidal activity against Rhizoctonia solani and could be used as potential lead compounds for further development of novel fungicides.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.