Baker’s Yeast Mediated Reduction of 2-Acetyl-3-methyl Sulfolane

Catalysts

Rebecca E. Deasy¹  Noreen O’Riordan¹ 

[1] Department of Chemistry, Analytical and Biological Chemistry Research Facility, University College Cork, Cork, Ireland; E-Mails:

关键词: baker’s yeast (Saccharomyces cerevisiae);    biocatalysis;    asymmetric reduction;    chiral alcohol;    sulfolane;   

DOI  :  10.3390/catal4020186

来源: mdpi

【 摘 要 】

The baker’s yeast mediated reduction of 2-acetyl-3-methyl sulfolane 1 to provide the corresponding alcohol 2 is described. Excellent efficiency and enantioselectivity (>98% ee) has been achieved under these mild environmentally benign reaction conditions. In direct contrast, the chemical reduction of 1 proceeds with poor yield (≤25%) and diastereocontrol.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.