Nutrients | |
Oligonol Supplementation Affects Leukocyte and Immune Cell Counts after Heat Loading in Humans | |
Jeong Beom Lee1  | |
[1] Department of Physiology, College of Medicine, Soonchunhyang University, 366-1, Ssangyong-dong, Cheonan, 331-946, Korea; E-Mail: | |
关键词: oligonol; leukocyte; lymphocyte; immune cell; heat; | |
DOI : 10.3390/nu6062466 | |
来源: mdpi | |
【 摘 要 】
Oligonol is a low-molecular-weight form of polyphenol and has antioxidant and anti-inflammatory activity, making it a potential promoter of immunity. This study investigates the effects of oligonol supplementation on leukocyte and immune cell counts after heat loading in 19 healthy male volunteers. The participants took a daily dose of 200 mg oligonol or a placebo for 1 week. After a 2-week washout period, the subjects were switched to the other study arm. After each supplement, half-body immersion into hot water was made, and blood was collected. Then, complete and differential blood counts were performed. Flow cytometry was used to enumerate and phenotype lymphocyte subsets. Serum concentrations of interleukin (IL)-1β and IL-6 in blood samples were analyzed. Lymphocyte subpopulation variables included counts of total T cells, B cells, and natural killer (NK) cells. Oligonol intake attenuated elevations in IL-1β (an 11.1-fold change
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190024735ZK.pdf | 200KB | download |