Amino Alcohols from the Ascidian Pseudodistoma sp

Marine Drugs

Tae Hyung Won²  Minjung You²  So-Hyoung Lee³  Boon Jo Rho¹  Dong-Chan Oh²  Ki-Bong Oh³ 

[1] Department of Biological Science, College of Life Science, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun, Seoul 120-750, Korea; E-Mail:;Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea; E-Mails:;Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea; E-Mail:

关键词: amino alcohols;    pseudoaminols;    Pseudodistoma sp.;    stereochemistry;    bioactivities;   

DOI  :  10.3390/md12063754

来源: mdpi

【 摘 要 】

Seven new amino alcohol compounds, pseudoaminols A–G (1–7), were isolated from the ascidian Pseudodistoma sp. collected off the coast of Chuja-do, Korea. Structures of these new compounds were determined by analysis of the spectroscopic data and from chemical conversion. The presence of an N-carboxymethyl group in two of the new compounds (6 and 7) is unprecedented among amino alcohols. Several of these compounds exhibited moderate antimicrobial activity and cytotoxicity, as well as weak inhibitory activity toward Na⁺/K⁺-ATPase.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.