New Dihydro-β-agarofuran Sesquiterpenes from Parnassia wightiana Wall: Isolation, Identification and Cytotoxicity against Cancer Cells

International Journal of Molecular Sciences

Chao Lv¹  Zuo-Lue Zheng¹  Fang Miao²  Hui-Ling Geng¹  Le Zhou¹ 

[1] College of Science, Northwest A&F University, Yangling 712100, China; E-Mails:;College of Life Science, Northwest A&F University, Yangling 712100, China; E-Mail:

关键词: dihydro-β-agarofuran;    sesquiterpene;    Parnassia wightiana;    cytotoxicity;   

DOI  :  10.3390/ijms150611111

来源: mdpi

【 摘 要 】

Five new (4–8) and three known (1–3) dihydro-β-agarofuran sesquiterpene polyesters were isolated from the whole plants of Parnassia wightiana. The structures of all compounds were elucidated through spectroscopic analysis including 2D-NMR and HR-MS. The absolute configuration of these compounds was established by X-ray diffraction analysis, comparison of NOESY spectra and biogenetic means. The cytotoxities of compounds 2–8 were evaluated in vitro against HL-60, SMMC-7721, A549, MCF-7 and SW480 cell lines. Compounds 5–7 exhibited the highest activities with IC₅₀ values of 11.8–30.1 μM in most cases. The SAR revealed that the introduction of hydroxyl group was able to significantly improve the activities of the compounds for most of the cell lines.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.