Bioactive Profiles, Antioxidant Activities, Nitrite Scavenging Capacities and Protective Effects on H2O2-Injured PC12 Cells of Glycyrrhiza Glabra L. Leaf and Root Extracts

Molecules

Yi Dong¹  Mouming Zhao¹  Tiantian Zhao¹  Mengying Feng¹  Huiping Chen¹  Mingzhu Zhuang¹ 

[1] College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China

关键词: Glycyrrhiza glabra L. leaf;    nitrite scavenging capacity;    tyrosinase inhibitory activity;    PC12 cells;    pinocembrin;    liquiritin;   

DOI  :  10.3390/molecules19079101

来源: mdpi

【 摘 要 】

This study compared the total flavonoid content of Glycyrrhiza glabra L. leaf and root extracts. Results suggested that the total flavonoid content in the leaf extract was obviously higher than that in the root extract. Pinocembrin, the main compound in the leaf extract after purification by column chromatography, showed good antioxidant activity and nitrite scavenging capacity, but moderate inhibitory effect on mushroom tyrosinase. Liquiritin was the main compound in root extract and possessed strong inhibitory effect on mushroom tyrosinase. Both compounds exhibited significant protection effect on H₂O₂-injured PC12 cells at a low concentration. These results indicate that Glycyrrhiza glabra L. leaf is potential as an important raw material for functional food.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.