RNA Virus Reverse Genetics and Vaccine Design

Viruses

Christopher C. Stobart¹ 

[1] Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA; E-Mail:

关键词: RNA virus;    reverse genetics;    vaccines;   

DOI  :  10.3390/v6072531

来源: mdpi

【 摘 要 】

RNA viruses are capable of rapid spread and severe or potentially lethal disease in both animals and humans. The development of reverse genetics systems for manipulation and study of RNA virus genomes has provided platforms for designing and optimizing viral mutants for vaccine development. Here, we review the impact of RNA virus reverse genetics systems on past and current efforts to design effective and safe viral therapeutics and vaccines.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.