Retinoic Acid Signaling during Early Spinal Cord Development

Journal of Developmental Biology

Ruth Diez del Corral¹ 

关键词: retinoic acid;    spinal cord;    neural tube;    axis elongation;    neural crest;    motor neuron;    dorso-ventral pattern;    rostro-caudal pattern;    neurogenesis;   

DOI  :  10.3390/jdb2030174

来源: mdpi

【 摘 要 】

Retinoic acid signaling is required at several steps during the development of the spinal cord, from the specification of generic properties to the final acquisition of neuronal subtype identities, including its role in trunk neural crest development. These functions are associated with the production of retinoic acid in specific tissues and are highly dependent on context. Here, we review the defects associated with retinoic acid signaling manipulations, mostly in chick and mouse models, trying to separate the different processes where retinoic acid signaling is involved and to highlight common features, such as its ability to promote transitions along the neuronal differentiation cascade.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.