MicroRNAs Control Macrophage Formation and Activation: The Inflammatory Link between Obesity and Cardiovascular Diseases

Cells

Richard Cheng-An Chang²  Wei Ying¹  Fuller W. Bazer¹ 

[1] Department of Animal Science, Texas A&M University, College Station, TX 77843, USA;Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843, USA

关键词: microRNA;    macrophage;    obesity;    cardiovascular diseases;   

DOI  :  10.3390/cells3030702

来源: mdpi

【 摘 要 】

Activation and recruitment of resident macrophages in tissues in response to physiological stress are crucial regulatory processes in promoting the development of obesity-associated metabolic disorders and cardiovascular diseases. Recent studies have provided compelling evidence that microRNAs play important roles in modulating monocyte formation, macrophage maturation, infiltration into tissues and activation. Macrophage-dependent systemic physiological and tissue-specific responses also involve cell-cell interactions between macrophages and host tissue niche cell components, including other tissue-resident immune cell lineages, adipocytes, vascular smooth muscle and others. In this review, we highlight the roles of microRNAs in regulating the development and function of macrophages in the context of obesity, which could provide insights into the pathogenesis of obesity-related metabolic syndrome and cardiovascular diseases.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.