Gut-Brain Endocrine Axes in Weight Regulation and Obesity Pharmacotherapy

Journal of Clinical Medicine

Dante J. Merlino¹  Erik S. Blomain¹  Amanda S. Aing¹ 

[1] Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 1020 Locust Street, JAH 368, Philadelphia, PA 19107, USA;

关键词: obesity;    satiety;    hypothalamus;    gut-brain endocrine axis;    pharmacotherapy;   

DOI  :  10.3390/jcm3030763

来源: mdpi

【 摘 要 】

In recent years, the obesity epidemic has developed into a major health crisis both in the United States as well as throughout the developed world. With current treatments limited to expensive, high-risk surgery and minimally efficacious pharmacotherapy, new therapeutic options are urgently needed to combat this alarming trend. This review focuses on the endogenous gut-brain signaling axes that regulate appetite under physiological conditions, and discusses their clinical relevance by summarizing the clinical and preclinical studies that have investigated manipulation of these pathways to treat obesity.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.