Synthesis and Phase Behavior of Poly(N-isopropylacrylamide)-b-Poly(L-Lysine Hydrochloride) and Poly(N-Isopropylacrylamide-co-Acrylamide)-b-Poly(L-Lysine Hydrochloride)

Materials

Milica Spasojević²  Joop Vorenkamp²  Mark R. P. A. C. S. Jansen²  Paul de Vos¹ 

[1] Department of Pathology and Medical Biology, Section of Immunoendocrinology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, EA11, 9700 RB Groningen, The Netherlands;Department of Polymer Chemistry, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands; E-Mails:

关键词: diblock copolymers;    ATRP;    ROP;    thermal behavior;   

DOI  :  10.3390/ma7075305

来源: mdpi

【 摘 要 】

The synthesis of poly(N-isopropylacrylamide)-b-poly(L-lysine) and poly(N-isopropylacrylamide-co-acrylamide)-b-poly(L-lysine) copolymers was accomplished by combining atom transfer radical polymerization (ATRP) and ring opening polymerization (ROP). For this purpose, a di-functional initiator with protected amino group was successfully synthetized. The ATRP of N-isopropylacrylamide yielded narrowly dispersed polymers with consistent high yields (~80%). Lower yields (~50%) were observed when narrowly dispersed random copolymers of N-isopropylacrylamide and acrylamide where synthesized. Amino-terminated poly(N-isopropylacrylamide) and poly(N-isopropylacrylamide-co-acrylamide) were successfully used as macroinitiators for ROP of N₆-carbobenzoxy-L-lysine N-carboxyanhydride. The thermal behavior of the homopolymers and copolymers in aqueous solutions was studied by turbidimetry, dynamic light scattering (DLS) and proton nuclear magnetic resonance spectroscopy (¹H-NMR).

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.