Improved Fibroblast Functionalities by Microporous Pattern Fabricated by Microelectromechanical Systems

International Journal of Molecular Sciences

Hongbo Wei³  Lingzhou Zhao¹  Bangdao Chen²  Shizhu Bai⁴ 

[1] State Key Laboratory of Military Stomatology, Department of Periodontology, School of Stomatology, the Fourth Military Medical University, No. 145 West Changle Road, Xi’an 710032, China;State Key Laboratory for Manufacturing Systems Engineering, Xi’an Jiaotong University, Xi’an 710048, China; E-Mail:;State Key Laboratory of Military Stomatology, Department of Oral Implant, School of Stomatology, the Fourth Military Medical University, No. 145 West Changle Road, Xi’an 710032, China; E-Mail:;State Key Laboratory of Military Stomatology, Department of Prosthodontics, School of Stomatology, the Fourth Military Medical University, No. 145 West Changle Road, Xi’an 710032, China; E-Mail:

关键词: fibroblasts;    microelectromechanical systems;    percutaneous implant;    microporous structure;    surface modification;   

DOI  :  10.3390/ijms150712998

来源: mdpi

【 摘 要 】

Fibroblasts, which play an important role in biological seal formation and maintenance, determine the long-term success of percutaneous implants. In this study, well-defined microporous structures with micropore diameters of 10–60 µm were fabricated by microelectromechanical systems and their influence on the fibroblast functionalities was observed. The results show that the microporous structures with micropore diameters of 10–60 µm did not influence the initial adherent fibroblast number; however, those with diameters of 40 and 50 µm improved the spread, actin stress fiber organization, proliferation and fibronectin secretion of the fibroblasts. The microporous structures with micropore diameters of 40–50 µm may be promising for application in the percutaneous part of an implant.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.