Clinical Significance of POU5F1P1 rs10505477 Polymorphism in Chinese Gastric Cancer Patients Receving Cisplatin-Based Chemotherapy after Surgical Resection

International Journal of Molecular Sciences

Lili Shen¹  Mulong Du⁵  Chun Wang¹  Dongying Gu¹  Meilin Wang⁵  Qi Zhang¹  Tingting Zhao¹  Xunlei Zhang⁴  Yongfei Tan²  Xinying Huo¹  Weida Gong³  Zhi Xu¹  Jinfei Chen¹ 

[1] Department of Oncology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China; E-Mails:;Department of Surgery, Yixing People’s Hospital, 75 Tongzhenguan Road, Yixing 214200, China; E-Mail:;Department of General Surgery, Yixing Tumor Hospital, 45 Dongshan East Road, Yixing 214200, China; E-Mail:;Department of Oncology, Nantong Tumor Hospital, Nantong 226000, 30 Tongyang North Road, China; E-Mail:;Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, 818 East Tianyuan Road, Nanjing 211166, China; E-Mails:

关键词: gastric cancer;    POU5F1P1 rs10505477 polymorphism;    single nucleotide polymorphism (SNP);    cisplatin-based chemotherapy;   

DOI  :  10.3390/ijms150712764

来源: mdpi

【 摘 要 】

This study aimed to investigate the association between POU class5 homeobox 1 pseudogene 1 gene (POU5F1P1) rs10505477 polymorphism and the prognosis of Chinese gastric cancer patients, who received cisplatin-based chemotherapy after surgical resection. POU5F1P1 rs10505477 was genotyped using the SNaPshot method in 944 gastric cancer patients who received gastrectomy. The association of rs10505477 G > A polymorphism with the progression and prognosis in gastric cancer patients was statistically analyzed using the SPSS version 18.0 for Windows. The results reveal that rs10505477 polymorphism has a negatively effect on the overall survival of gastric cancer patients in cisplatin-based chemotherapy subgroup (HR = 1.764, 95% CI = 1.069–2.911, p = 0.023). Our preliminary study indicates for the first time that POU5F1P1 rs10505477 is correlated with survival of gastric cancer patients who receving cisplatin-based chemotherapy after gastrectomy. Further studies are warranted to investigate the mechanism and to verify our results in different populations.

【 授权许可】

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