Receptor for Advanced Glycation End Products (RAGE) and Its Ligands: Focus on Spinal Cord Injury

International Journal of Molecular Sciences

Juhyun Song¹  Won Taek Lee¹  Kyung Ah Park¹ 

[1] Department of Anatomy, Yonsei University College of Medicine, Seoul 120-752, Korea; E-Mails:

关键词: receptor for advanced glycation end products (RAGE);    spinal cord injury (SCI);    inflammation;    neurite outgrowth;    Schwann cell;   

DOI  :  10.3390/ijms150813172

来源: mdpi

【 摘 要 】

Spinal cord injury (SCI) results in neuronal and glial death and the loss of axons at the injury site. Inflammation after SCI leads to the inhibition of tissue regeneration and reduced neuronal survival. In addition, the loss of axons after SCI results in functional loss below the site of injury accompanied by neuronal cell body’s damage. Consequently, reducing inflammation and promoting axonal regeneration after SCI is a worthy therapeutic goal. The receptor for advanced glycation end products (RAGE) is a transmembrane protein and receptor of the immunoglobulin superfamily. RAGE is implicated in inflammation and neurodegeneration. Several recent studies demonstrated an association between RAGE and central nervous system disorders through various mechanisms. However, the relationship between RAGE and SCI has not been shown. It is imperative to elucidate the association between RAGE and SCI, considering that RAGE relates to inflammation and axonal degeneration following SCI. Hence, the present review highlights recent research regarding RAGE as a compelling target for the treatment of SCI.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.