Polyphenols with Anti-Proliferative Activities from Penthorum Chinense Pursh

Molecules

Doudou Huang¹  Yun Jiang³  Wansheng Chen²  Fengyan Yao¹ 

[1] Department of Identification of Traditional Chinese Medicine, School of Pharmacy, Second Military Medical University, Shanghai 200433, China; E-Mails:;Department of Pharmacy, Changzheng Hospital, Shanghai 200003, China; E-Mail:;State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, Macau, China; E-Mail:

关键词: Penthorum chinense;    polyphenols;    anti-proliferative activity;   

DOI  :  10.3390/molecules190811045

来源: mdpi

【 摘 要 】

Two new polyphenols, penthorumin C (1) and 2,6-dihydroxyacetophenone-4-O-[4ꞌ,6ꞌ-(S)-hexahydroxydiphenoyl]-β-d-glucose (2), along with four known polyphenolic acids, pinocembrin-7-O-[4ꞌꞌ,6ꞌꞌ-hexahydroxydiphenoyl]-β-d-glucose(3), pinocembrin-7-O-[3ꞌꞌ-O-galloyl- 4ꞌꞌ,6ꞌꞌ-hexahydroxydiphenoyl]-β-d-glucose (4), thonningianin A (5), and thonningianin B (6) were isolated from Penthourm chinense. All compounds were evaluated for their anti-proliferative activity in HSC-T6 cells, and 2 and 5 showed significant activity, with IC₅₀ values of 12.7 and 19.2 μM, respectively.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.