International Journal of Molecular Sciences | |
Xiaojuan Quan1  Lin Zhang2  Yingna Li2  | |
[1]Department of Geriatrics, the Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an 710004, China | |
关键词: β-cells; free fatty acids; TCF2; insulin; reactive oxygen species; | |
DOI : 10.3390/ijms150813317 | |
来源: mdpi | |
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【 摘 要 】
Free fatty acids (FFAs) are cytotoxic to pancreatic islet β-cells and play a crucial role in the diabetes disease process. A recent study revealed a down-regulation of transcription factor 2 (TCF2) levels during FFA-mediated cytotoxicity in pancreatic β-cells. However, its function during this process and the underlying mechanism remains unclear. In this study, treatment with palmitic acid (PA) at high levels (400 and 800 μM) decreased β-cell viability and TCF2 protein expression, along with the glucose-stimulated insulin secretion (GSIS). Western and RT-PCR analysis confirmed the positive regulatory effect of
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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