Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults

Cancers

Gypsyamber D’Souza²  Nicole Kluz²  Alicia Wentz²  Renee M. Youngfellow³  Anne Griffioen²  Emily Stammer²  Yingshi Guo¹  Weihong Xiao¹ 

[1] Ohio State University Comprehensive Cancer Center, Columbus, OH 43202, USA; E-Mails:;Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA; E-Mails:;Baltimore County Health Department, Baltimore, MD 21212, USA; E-Mail:

关键词: oral HPV;    young adults;    STD clinic;    gender;   

DOI  :  10.3390/cancers6031691

来源: mdpi

【 摘 要 】

Oral HPV infection, the cause of most oropharyngeal cancer in the U.S., is not well studied among high-risk young adults. Men (n = 340) and women (n = 270) aged 18–25 years attending Baltimore County STD clinics were recruited if they declined HPV vaccination. Each participant had a 30-second oral rinse and gargle sample tested for 37 types of HPV DNA, and a risk-factor survey. Factors associated with prevalent infection were explored using log binomial regression. Men had higher prevalence of any oral HPV (15.3% vs. 7.8%, p = 0.004) and vaccine-type oral HPV (i.e., HPV16/18/6/11: 5.0% vs. 1.1%, p = 0.007) infection than women. In multivariate analysis, male gender (aPR = 1.93, 95% CI = 1.10–3.39), number of recent oral sex partners (p-trend = 0.013) and having ever performed oral sex on a woman (aPR = 1.73, 95% CI = 1.06–2.82) were associated with increased oral HPV prevalence. Performing oral sex on a woman may confer higher risk of oral HPV acquisition than performing oral sex on a man.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.