Release of Insulin from Calcium Carbonate Microspheres with and without Layer-by-Layer Thin Coatings

Polymers

Katsuhiko Sato¹  Masaru Seno¹ 

[1] Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan;

关键词: microsphere;    polymer coating;    calcium carbonate;    insulin delivery;    layer-by-layer film;    controlled release;   

DOI  :  10.3390/polym6082157

来源: mdpi

【 摘 要 】

The release of insulin from insulin-containing CaCO₃ microspheres was investigated. The microspheres were prepared by mixing aqueous solutions of CaCl₂ and Na₂CO₃ in the presence of insulin. The surface of the insulin-containing CaCO₃ microspheres was coated with a layer-by-layer thin film consisting of poly(allylamine hydrochloride) and poly(styrene sulfonate) to regulate the release kinetics of insulin. The release rate of insulin from the coated CaCO₃ microspheres was significantly suppressed compared with that of uncoated CaCO₃ microspheres, and depended on the thickness of the films. Rhombohedral calcite crystals of CaCO₃ formed from the microspheres during the release of insulin, suggesting that the CaCO₃ microspheres dissolved and recrystallized during the release of insulin.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.