Non-Coding RNAs and Lipid Metabolism

International Journal of Molecular Sciences

Elisabeth Smolle¹ 

[1] Institute of Pathology, Medical University Graz, Auenbruggerplatz 25, A-8036 Graz, Austria; E-Mail

关键词: non-coding RNAs;    micro RNAs;    long non-coding RNAs;    dyslipidaemia;   

DOI  :  10.3390/ijms150813494

来源: mdpi

【 摘 要 】

A high percentage of the mammalian genome consists of non-coding RNAs (ncRNAs). Among ncRNAs two main subgroups have been identified: long ncRNAs (lncRNAs) and micro RNAs (miRNAs). ncRNAs have been demonstrated to play a role in a vast variety of diseases, since they regulate gene transcription and are involved in post-transcriptional regulation. They have the potential to function as molecular signals or as guides for transcription factors and to regulate epigenetic modifiers. In this literature review we have summarized data on miRNAs and lncRNAs and their involvement in dyslipidaemia, atherosclerosis, insulin resistance and adipogenesis. Outlining certain ncRNAs as disease biomarkers and/or therapeutic targets, and testing them in vivo, will be the next steps in future research.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.