Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents

Molecules

Arianna Giovine²  Marilena Muraglia²  Marco Antonio Florio²  Antonio Rosato²  Filomena Corbo¹  Carlo Franchini²  Biagia Musio²  Leonardo Degennaro² 

[1] Department of Pharmacy-Drug Science, University of Bari “A. Moro”, Via E.Orabona 4, Bari 70125, Italy;

关键词: aziridines;    boron compounds;    Suzuki-Miyaura;    palladium coupling;    antibiotics;   

DOI  :  10.3390/molecules190811505

来源: mdpi

【 摘 要 】

By using the Suzuki-Miyaura protocol, a simple straightforward synthesis of functionalized 2-arylaziridines has been developed. By means of this synthetic strategy from readily available ortho-, meta- and para-bromophenylaziridines and aryl- or heteroarylboronic acids, new aziridines could be obtained. The cross-coupling reactions occurred without ring opening of the three membered ring. Preliminary results on the antimicrobial activity of the heterosubstituted biaryl compounds have been also included.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.