Recent Advances of Stem Cell Therapy for Retinitis Pigmentosa

International Journal of Molecular Sciences

Yuxi He¹  Yan Zhang¹  Xin Liu²  Emma Ghazaryan²  Ying Li²  Jianan Xie² 

[1] Department of Ophthalmology, Second Hospital, Jilin University, Ziqiang Street No. 218, Changchun 130041, Jilin, China;

关键词: retinitis pigmentosa;    bone marrow-derived mesenchymal stem cells;    stem cell transplantation;   

DOI  :  10.3390/ijms150814456

来源: mdpi

【 摘 要 】

Retinitis pigmentosa (RP) is a group of inherited retinal disorders characterized by progressive loss of photoreceptors and eventually leads to retina degeneration and atrophy. Until now, the exact pathogenesis and etiology of this disease has not been clear, and many approaches for RP therapies have been carried out in animals and in clinical trials. In recent years, stem cell transplantation-based attempts made some progress, especially the transplantation of bone marrow-derived mesenchymal stem cells (BMSCs). This review will provide an overview of stem cell-based treatment of RP and its main problems, to provide evidence for the safety and feasibility for further clinical treatment.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.