Liquid Phase Sintered Ceramic Bone Scaffolds by Combined Laser and Furnace

International Journal of Molecular Sciences

Pei Feng¹  Youwen Deng²  Songlin Duan¹  Chengde Gao¹  Cijun Shuai¹ 

[1] State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China; E-Mails:;Department of Spine Surgery, the Second Xiangya Hospital of Central South University, Changsha 410011, China; E-Mail:

关键词: bone scaffolds;    liquid phase;    45S5;    mechanical properties;    bioactivity;   

DOI  :  10.3390/ijms150814574

来源: mdpi

【 摘 要 】

Fabrication of mechanically competent bioactive scaffolds is a great challenge in bone tissue engineering. In this paper, β-tricalcium phosphate (β-TCP) scaffolds were successfully fabricated by selective laser sintering combined with furnace sintering. Bioglass 45S5 was introduced in the process as liquid phase in order to improve the mechanical and biological properties. The results showed that sintering of β-TCP with the bioglass revealed some features of liquid phase sintering. The optimum amount of 45S5 was 5 wt %. At this point, the scaffolds were densified without defects. The fracture toughness, compressive strength and stiffness were 1.67 MPam^1/2, 21.32 MPa and 264.32 MPa, respectively. Bone like apatite layer was formed and the stimulation for apatite formation was increased with increase in 45S5 content after soaking in simulated body fluid, which indicated that 45S5 could improve the bioactivity. Furthermore, MG-63 cells adhered and spread well, and proliferated with increase in the culture time.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.