Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis (EAE)

Molecules

Dປora S. Dias³  Lívia B. A. Fontes³  Antônio E. M. Crotti²  Beatriz J. V. Aarestrup¹  Fernando M. Aarestrup¹  Ademar A. da Silva Filho³ 

[1] Laboratory of Experimental Imunology and Patology, CBR, Federal University of Juiz de Fora, Juiz de Fora, R. José Lourenço Kelmer s/n, Campus Universitário, 36036-900 Juiz de Fora, MG, Brazil;Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, 14040-901 Ribeirão Preto, SP, Brazil;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Juiz de Fora, R. José Lourenço Kelmer s/n, Campus Universitário, 36036-900 Juiz de Fora, MG, Brazil

关键词: multiple sclerosis;    experimental autoimmune encephalomyelitis;    natural products;    immunomodulatory;    copaiba oil;   

DOI  :  10.3390/molecules190812814

来源: mdpi

【 摘 要 】

Experimental autoimmune encephalomyelitis (EAE) is a murine autoimmune disease used to study multiple sclerosis. We have investigated the immunomodulatory effects of copaiba oil (100, 50 and 25 µg/mL) on NO, H₂O₂, TNF-α, IFN-γ and IL-17 production in cultured cells from EAE-mice. Copaiba oil (100 µg/mL) inhibited H₂O₂, NO, IFN-γ TNF-α and IL-17 production spontaneously or after ConA and MOG_35–55 stimulation. It is suggested that copaiba oil acts on the mechanism of development of EAE by IFN-γ, IL-17 and TNF-α inhibition, modulating the immune response on both Th1 and Th17 cells.

【 授权许可】

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