International Journal of Molecular Sciences | |
Simvastatin Attenuates the Oxidative Stress, Endothelial Thrombogenicity and the Inducibility of Atrial Fibrillation in a Rat Model of Ischemic Heart Failure | |
Kyoung-Im Cho1  Sang-Ho Koo1  Tae-Joon Cha2  Jung-Ho Heo1  Hyun-Su Kim1  Gee-Bum Jo1  | |
[1] Division of Cardiology, Department of Internal Medicine, Kosin University College of Medicine, Busan 602702, Korea; | |
关键词: statin; atrial fibrillation; nitric oxide synthase; heart failure; | |
DOI : 10.3390/ijms150814803 | |
来源: mdpi | |
【 摘 要 】
Increased atrial oxidative stress has an important role in inducing and maintaining atrial fibrillation (AF), and the activation of the small GTPase Rac1 contributes to the oxidative stress. We investigated the relationship of Rac1, atrial endothelial thromboprotective markers and AF inducibility and if simvastatin has a potential beneficial effect on a myocardial infarction (MI)-induced heart failure (HF) rat model. Rats were randomized into three groups (shams, MI group and simvastatin treatment group) and underwent echocardiography, AF induction studies and left atrial (LA) fibrosis analysis. Atrial Rac 1, sodium calcium exchanger (
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190022589ZK.pdf | 9906KB | download |