Canine Enteric Coronaviruses: Emerging Viral Pathogens with Distinct Recombinant Spike Proteins

Viruses

Beth N. Licitra¹  Gerald E. Duhamel² 

[1] Department of Microbiology & Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA; E-Mail:;Department of Biomedical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA; E-Mail:

关键词: canine coronavirus;    viral pathogenesis;    spike protein;    recombination;   

DOI  :  10.3390/v6083363

来源: mdpi

【 摘 要 】

Canine enteric coronavirus (CCoV) is an alphacoronavirus infecting dogs that is closely related to enteric coronaviruses of cats and pigs. While CCoV has traditionally caused mild gastro-intestinal clinical signs, there are increasing reports of lethal CCoV infections in dogs, with evidence of both gastrointestinal and systemic viral dissemination. Consequently, CCoV is now considered to be an emerging infectious disease of dogs. In addition to the two known serotypes of CCoV, novel recombinant variants of CCoV have been found containing spike protein N-terminal domains (NTDs) that are closely related to those of feline and porcine strains. The increase in disease severity in dogs and the emergence of novel CCoVs can be attributed to the high level of recombination within the spike gene that can occur during infection by more than one CCoV type in the same host.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.