Protoberberine Isoquinoline Alkaloids from Arcangelisia gusanlung

Molecules

Ling-Ling Yu²  Rong-Tao Li³  Yuan-Bao Ai⁴  Wei Liu⁴  Zhang-Shuang Deng¹ 

[1] China Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, China; E-Mail:;Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, China; E-Mail:;Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Wanning 571533, China; E-Mail:;School of Medicine, China Three Gorges University, Yichang 443002, China; E-Mails:

关键词: protoberberine alkaloid;    Arcangelisia gusanlung;    gusanlung E;   

DOI  :  10.3390/molecules190913332

来源: mdpi

【 摘 要 】

HPLC-DAD-directed isolation and purification of the methanol extract of stems of Arcangelisia gusanlung H. S. Lo. led to the isolation of a new protoberberine alkaloid, gusanlung E (1), along with fourteen known derivatives 2–15, seven of which were obtained from the genus Arcangelisia for the first time. The structures and absolute stereochemistry of these compounds were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR, mass spectrometry, and CD analyses. Gusanlung E (1) expressed weak cytotoxic activity against the SGC 7901 cell line with an IC₅₀ value of 85.1 µM.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.