Microwave Assisted Convenient One-Pot Synthesis of Coumarin Derivatives via Pechmann Condensation Catalyzed by FeF3 under Solvent-Free Conditions and Antimicrobial Activities of the Products

Molecules

Vahid Vahabi¹ 

关键词: coumarin;    solvent-free;    FeF3;    one-pot;    microwave irradiation;    antimicrobial activities;   

DOI  :  10.3390/molecules190913093

来源: mdpi

【 摘 要 】

A rapid and efficient solvent-free one-pot synthesis of coumarin derivatives by Pechmann condensation reactions of phenols with ethyl acetoacetate using FeF₃ as a catalyst under microwave irradiation is described. This one-pot synthesis on a solid inorganic support provides the products in good yields. The newly synthesized compounds were systematically characterized by IR, ¹H-NMR, ¹³C-NMR, MS and elemental CHN analyses. The proposed solvent-free microwave irradiation method using the environmentally friendly catalyst FeF₃ offers the unique advantages of high yields, shorter reaction times, easy and quick isolation of the products, excellent chemoselectivity, and a one-pot, green synthesis. The products were screened for antimicrobial activity, and the results showed that the compounds reacted against all the tested bacteria.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.