The Three Integrated Phases of Left Atrial Macrophysiology and Their Interactions

International Journal of Molecular Sciences

Raman Mehrzad¹  Mohammad Rajab² 

[1] Department of Medicine, Steward Carney Hospital, Tufts University School of Medicine, 2100 Dorchester Avenue, Boston, MA 02124, USA;Department of Medicine, Division of Cardiology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA; E-Mail:

关键词: left atrium;    macrophysiology;    phases;    integrated;    interactions;   

DOI  :  10.3390/ijms150915146

来源: mdpi

【 摘 要 】

Our understanding of the left atrium is growing, although there are many aspects that are still poorly understood. The left atrium size as an imaging biomarker has been consistently shown to be a powerful predictor of outcomes and of different cardiovascular disorders, such as, but not limited to, atrial fibrillation, congestive heart failure, mitral regurgitation and stroke. Left atrial function has been conventionally divided into three integrated phases: reservoir, conduit and booster-pump. The highly dynamic left atrium and its response to the stretch and secretion of atrial neuropeptides leaves the left atrium far from being a simple transport chamber. The aim of this review is to provide an understanding of the left atrial physiology and its relation to disorders within the heart.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.