International Journal of Molecular Sciences | |
The G-Protein-Coupled Estrogen Receptor (GPER/GPR30) in Ovarian Granulosa Cell Tumors | |
Sabine Heublein3  Doris Mayr1  Klaus Friese3  Maria Cristina Jarrin-Franco1  Miriam Lenhard4  Artur Mayerhofer2  | |
[1] Department of Pathology, Ludwig-Maximilians-University of Munich, 80337 Munich, Germany; E-Mails:;Department of Anatomy III, Cell Biology, Ludwig-Maximilians-University of Munich, 80336 Munich, Germany; E-Mail:;Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University of Munich, Campus Innenstadt, 80337 Munich, Germany; E-Mails:;Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University of Munich, Campus Großhadern, 81377 Munich, Germany; E-Mail: | |
关键词: GPER; GPR30; ovarian granulosa cell tumor; | |
DOI : 10.3390/ijms150915161 | |
来源: mdpi | |
【 摘 要 】
Ovarian granulosa cell tumors (GCTs) are thought to arise from cells of the ovarian follicle and comprise a rare entity of ovarian masses. We recently identified the G-protein-coupled estrogen receptor (GPER/GPR30) to be present in granulosa cells, to be regulated by gonadotropins in epithelial ovarian cancer and to be differentially expressed throughout folliculogenesis. Thus, supposing a possible role of GPER in GCTs, this study aimed to analyze GPER in GCTs. GPER immunoreactivity in GCTs (
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
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