Potential Therapeutic Roles of Tanshinone IIA in Human Bladder Cancer Cells

International Journal of Molecular Sciences

Sheng-Chun Chiu¹  Sung-Ying Huang³  Shu-Fang Chang¹  Shee-Ping Chen²  Chi-Cheng Chen⁵  Tien-Huang Lin⁵  Hsin-Ho Liu⁵  Tsung-Hsun Tsai⁵  Shang-Sen Lee⁵  Cheng-Yoong Pang⁴ 

[1] Department of Research, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 88, Section 1, Fengxing Road, Tanzi Dist., Taichung 427, Taiwan; E-Mails:;Tzu Chi Stem Cells Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 707, Section 3, Chung-Yang Road, Hualien 970, Taiwan; E-Mail:;Department of Ophthalmology, Mackay Memorial Hospital, No. 690, Section 2, Guangfu Road, East Dist., Hsinchu 30071, Taiwan; E-Mail:;Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 707, Section 3, Chung-Yang Road, Hualien 970, Taiwan;Department of Urology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 88, Section 1, Fengxing Road, Tanzi Dist., Taichung 427, Taiwan; E-Mails:

关键词: Tanshinone IIA;    bladder cancer;    metastasis;    cisplatin;    combination therapy;   

DOI  :  10.3390/ijms150915622

来源: mdpi

【 摘 要 】

Tanshinone IIA (Tan-IIA), one of the major lipophilic components isolated from the root of Salviae Miltiorrhizae, has been found to exhibit anticancer activity in various cancer cells. We have demonstrated that Tan-IIA induces apoptosis in several human cancer cells through caspase- and mitochondria-dependent pathways. Here we explored the anticancer effect of Tan-IIA in human bladder cancer cell lines. Our results showed that Tan-IIA caused bladder cancer cell death in a time- and dose-dependent manner. Tan-IIA induced apoptosis through the mitochondria-dependent pathway in these bladder cancer cells. Tan-IIA also suppressed the migration of bladder cancer cells as revealed by the wound healing and transwell assays. Finally, combination therapy of Tan-IIA with a lower dose of cisplatin successfully killed bladder cancer cells, suggesting that Tan-IIA can serve as a potential anti-cancer agent in bladder cancer.

【 授权许可】

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.