EPAS-1 Mediates SP-1-Dependent FBI-1 Expression and Regulates Tumor Cell Survival and Proliferation

International Journal of Molecular Sciences

Xiaogang Wang¹  Peng Cao¹  Zhiqing Li¹  Dongyang Wu¹  Xi Wang² 

[1] Department of Neurosurgery, Institute of Neurology, General Hospital of Shenyang Military Area Command, Shenyang 110016, China; E-Mails:;Institute of Neuroscience, Fourth Military Medical University, Xi’an 710032, China; E-Mail:

关键词: factor binding IST-1;    specificity protein-1;    endothelial pas domain protein-1;    transcription factor;    tumorigenesis;   

DOI  :  10.3390/ijms150915689

来源: mdpi

【 摘 要 】

Factor binding IST-1 (FBI-1) plays an important role in oncogenic transformation and tumorigenesis. As FBI-1 is over-expressed in multiple human cancers, the regulation of itself would provide new effective options for cancer intervention. In this work, we aimed to study the role that EPAS-1 plays in regulating FBI-1. We use the fact that specificity protein-1 (SP-1) is one of the crucial transcription factors of FBI-1, and that SP-1 can interact with the endothelial pas domain protein-1 (EPAS-1) for the induction of hypoxia related genes. The study showed that EPAS-1 plays an indispensible role in SP-1 transcription factor-mediated FBI-1 induction, and participated in tumor cell survival and proliferation. Thus, EPAS-1 could be a novel target for cancer therapeutics.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.