The Aging Kidney: Increased Susceptibility to Nephrotoxicity

International Journal of Molecular Sciences

Xinhui Wang¹  Joseph V. Bonventre² 

[1] Department of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, MO 65212, USA; E-Mail:;Renal Division and Biomedical Engineering Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA; E-Mail:

关键词: aging;    acute kidney injury (AKI);    chronic kidney disease (CKD);    nephrotoxicity;   

DOI  :  10.3390/ijms150915358

来源: mdpi

【 摘 要 】

Three decades have passed since a series of studies indicated that the aging kidney was characterized by increased susceptibility to nephrotoxic injury. Data from these experimental models is strengthened by clinical data demonstrating that the aging population has an increased incidence and severity of acute kidney injury (AKI). Since then a number of studies have focused on age-dependent alterations in pathways that predispose the kidney to acute insult. This review will focus on the mechanisms that are altered by aging in the kidney that may increase susceptibility to injury, including hemodynamics, oxidative stress, apoptosis, autophagy, inflammation and decreased repair.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.