Resveratrol Induces the Expression of Interleukin-10 and Brain-Derived Neurotrophic Factor in BV2 Microglia under Hypoxia

International Journal of Molecular Sciences

Juhyun Song²  So Yeong Cheon²  Wonsug Jung¹  Won Taek Lee² 

[1] Department of Anatomy, Gachon University School of Medicine, Incheon 406-799, Korea; E-Mail:;Department of Anatomy, Yonsei University College of Medicine, Seoul 120-752, Korea; E-Mails:

关键词: resveratrol;    microglia;    hypoxia;    nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB);    interleukin-10 (IL-10);    brain-derived neurotrophic factor (BDNF);   

DOI  :  10.3390/ijms150915512

来源: mdpi

【 摘 要 】

Microglia are the resident macrophages of the central nervous system (CNS) and play an important role in neuronal recovery by scavenging damaged neurons. However, overactivation of microglia leads to neuronal death that is associated with CNS disorders. Therefore, regulation of microglial activation has been suggested to be an important target for treatment of CNS diseases. In the present study, we investigated the beneficial effect of resveratrol, a natural phenol with antioxidant effects, in the microglial cell line, BV2, in a model of hypoxia injury. Resveratrol suppressed the mRNA expression of the pro-inflammatory molecule, tumor necrosis factor-α, and promoted the mRNA expression of the anti-inflammatory molecule, interleukin-10, in BV2 microglia under hypoxic conditions. In addition, resveratrol inhibited the activation of the transcription factor, nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB), which is upstream in the control of inflammatory reactions in hypoxia-injured BV2 microglia. Moreover, resveratrol promoted the expression of brain-derived neurotrophic factor (BDNF) in BV2 microglia under hypoxic stress. Overall, resveratrol may promote the beneficial function of microglia in ischemic brain injury.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.