Various On-Chip Sensors with Microfluidics for Biological Applications

Sensors

Hun Lee¹  Linfeng Xu¹  Domin Koh¹  Nikhila Nyayapathi¹ 

[1] Department of Electrical Engineering, University at Buffalo, State University of New York (SUNY at Buffalo), Buffalo, NY 14260, USA;

关键词: SPR;    SERS;    image sensor;    smart phone;    microfluidic chip;   

DOI  :  10.3390/s140917008

来源: mdpi

【 摘 要 】

In this paper, we review recent advances in on-chip sensors integrated with microfluidics for biological applications. Since the 1990s, much research has concentrated on developing a sensing system using optical phenomena such as surface plasmon resonance (SPR) and surface-enhanced Raman scattering (SERS) to improve the sensitivity of the device. The sensing performance can be significantly enhanced with the use of microfluidic chips to provide effective liquid manipulation and greater flexibility. We describe an optical image sensor with a simpler platform for better performance over a larger field of view (FOV) and greater depth of field (DOF). As a new trend, we review consumer electronics such as smart phones, tablets, Google glasses, etc. which are being incorporated in point-of-care (POC) testing systems. In addition, we discuss in detail the current optical sensing system integrated with a microfluidic chip.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.