Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid

International Journal of Molecular Sciences

Anthony Arlia-Ciommo¹  Amanda Piano¹  Veronika Svistkova¹  Sadaf Mohtashami¹ 

关键词: bioactive lipids;    lipid metabolism;    lipidomics;    bile acids;    aging and age-related diseases;    cancer;    anti-aging and anti-tumor therapeutic agents;    endoplasmic reticulum;    mitochondria;    cell death;   

DOI  :  10.3390/ijms150916522

来源: mdpi

【 摘 要 】

Bile acids are cholesterol-derived bioactive lipids that play essential roles in the maintenance of a heathy lifespan. These amphipathic molecules with detergent-like properties display numerous beneficial effects on various longevity- and healthspan-promoting processes in evolutionarily distant organisms. Recent studies revealed that lithocholic bile acid not only causes a considerable lifespan extension in yeast, but also exhibits a substantial cytotoxic effect in cultured cancer cells derived from different tissues and organisms. The molecular and cellular mechanisms underlying the robust anti-aging and anti-tumor effects of lithocholic acid have emerged. This review summarizes the current knowledge of these mechanisms, outlines the most important unanswered questions and suggests directions for future research.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.