Pharmacological Effects of “Jutsu” (Atractylodis rhizome and Atractylodis lanceae rhizome) on 1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-Induced Head Twitch Response in Mice (I)

Molecules

Chiaki Murayama¹  Ching-Chiung Wang²  Seiwa Michihara¹ 

[1] Kampo Research Laboratories, Kracie Pharma Ltd., Kanebo machi 3-1, Takaoka, Toyama 933-0856, Japan; E-Mails:;School of Pharmacy, College of Pharmacy, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan; E-Mail:

关键词: hallucinations;    Atractylodis rhizome (Byaku-jutsu);    Atractylodis lanceaerhizome (So-jutsu);    atractylenolide III;    β-eudesmol;    DOI-induced head-twitch;   

DOI  :  10.3390/molecules190914979

来源: mdpi

【 摘 要 】

Hallucinations are a common non-motor symptom of Parkinson’s disease and various forms of dementias. Yokukansan and Yokukansankachimpihange have attracted attention due to their effectiveness in the treatment of hallucinations of dementia. To clarify which component in these formulas contribute to the effects, at first, we focused on their differences in compositions to examine the pharmacological effects on the selective 5-HT_2A/2C agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced head-twitch response (HTR) in mice that has been used as animal hallucination model. Results indicated that water extract of Byaku-jutsu (Atractylodes japonica) showed a stronger inhibitory effect on DOI-induced HTR than that of So-jutsu (A. lancea) corresponding to their major constituents of atractylenolide III and β-eudesmol, and suggested that the major constituents should be active constituents contributing to the antihallucination effects of Byaku- and So-jutsu. Besides, the part B–C ring (butenolide) in atractylenolide III was found to be similar to the structure of serotonin and suggested that the B–C ring may partially play role in antagonistic activity against serotonin receptors. Thus, a novel, rational design of butenolide-related compounds may as potential lead compounds for new drug development. Analysis of the chemical components of Byaku- and So-jutsu and further study on their structure-activity relationships are currently in progress.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.