Synthesis, Characterization and in Vitro Evaluation of New Composite Bisphosphonate Delivery Systems

International Journal of Molecular Sciences

Joanna Kolmas¹  Marcin Sobczak¹  Ewa Olᆝzka¹  Grzegorz Nałᆜz-Jawecki² 

[1] Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, Poland; E-Mails:;Department of Environmental Health Science, Faculty of Pharmacy, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, Poland; E-Mail:

关键词: polymeric biomaterials;    bisphosphonates;    polyurethanes;    hydroxyapatite;    drug delivery systems;    clodronate;   

DOI  :  10.3390/ijms150916831

来源: mdpi

【 摘 要 】

In this study, new composite bisphosphonate delivery systems were obtained from polyurethanes (PUs) and nanocrystalline hydroxyapatite (HA). The biodegradable PUs were first synthesized from poly(ε-caprolactone) diols (PCL diols), poly(ethylene adipate) diol, 1,6-hexamethylene diisocyanate, 1,4-butanediol and HA. Moreover, the PCL diols were synthesized by the ring-opening polymerization catalysed by the lipase from Candida antarctica. Next, composite drug delivery systems for clodronate were prepared. The mechanical properties of the obtained biomaterials were determined. The cytotoxicity of the synthesized polymers was tested. The preliminary results show that the obtained composites are perspective biomaterials and they can be potentially applied in the technology of implantation drug delivery systems.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.