The Role of 8-Oxoguanine DNA Glycosylase-1 in Inflammation

International Journal of Molecular Sciences

Xueqing Ba¹  Leopoldo Aguilera-Aguirre¹  Qura Tul Ain Nmi Rashid³  Attila Bacsi¹  Zsolt Radak¹  Sanjiv Sur³  Koa Hosoki³  Muralidhar L. Hegde² 

[1] Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA; E-Mails:;Radiation Oncology and Neurology, Houston Methodist Research Institute, Houston, TX 77030, USA; E-Mail:;Departments of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA; E-Mails:

关键词: OGG1;    DNA base excision repair;    8-oxoG base;    small GTPases;    inflammation;   

DOI  :  10.3390/ijms150916975

来源: mdpi

【 摘 要 】

Many, if not all, environmental pollutants/chemicals and infectious agents increase intracellular levels of reactive oxygen species (ROS) at the site of exposure. ROS not only function as intracellular signaling entities, but also induce damage to cellular molecules including DNA. Among the several dozen ROS-induced DNA base lesions generated in the genome, 8-oxo-7,8-dihydroguanine (8-oxoG) is one of the most abundant because of guanine’s lowest redox potential among DNA bases. In mammalian cells, 8-oxoG is repaired by the 8-oxoguanine DNA glycosylase-1 (OGG1)-initiated DNA base excision repair pathway (OGG1–BER). Accumulation of 8-oxoG in DNA has traditionally been associated with mutagenesis, as well as various human diseases and aging processes, while the free 8-oxoG base in body fluids is one of the best biomarkers of ongoing pathophysiological processes. In this review, we discuss the biological significance of the 8-oxoG base and particularly the role of OGG1–BER in the activation of small GTPases and changes in gene expression, including those that regulate pro-inflammatory chemokines/cytokines and cause inflammation.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.