Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury

Cells

Eunhyun Choi¹  Min-Ji Cha¹ 

[1] Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do 210-701, Korea; E-Mails:

关键词: microRNA;    calcium;    Ca²⁺;    myocardial ischemia-reperfusion injury;    heart;   

DOI  :  10.3390/cells3030899

来源: mdpi

【 摘 要 】

Cardiac Ca²⁺ cycling and signaling are closely associated with cardiac function. Changes in cellular Ca²⁺ homeostasis may lead to aberrant cardiac rhythm and may play a critical role in the pathogenesis of cardiac diseases, due to their exacerbation of heart failure. MicroRNAs (miRNAs) play a key role in the regulation of gene expression at the post-transcriptional level and participate in regulating diverse biological processes. The emerging evidence indicates that the expression profiles of miRNAs vary among human diseases, including cardiovascular diseases. Cardiac Ca²⁺-handling and signaling proteins are also regulated by miRNAs. Given the relationship between cardiac Ca²⁺ homeostasis and signaling and miRNA, Ca²⁺-related miRNAs may serve as therapeutic targets during the treatment of heart failure. In this review, we summarize the knowledge currently available regarding the role of Ca²⁺ in cardiac function, as well as changes in Ca²⁺ cycling and homeostasis and the handling of these processes by miRNAs during cardiac ischemia-reperfusion injury.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.