International Journal of Molecular Sciences | |
Prophylactic Protective Effects and Its Potential Mechanisms of IcarisideII on Streptozotocin Induced Spermatogenic Dysfunction | |
Yongde Xu2  Hongen Lei2  Ruili Guan2  Zhezhu Gao2  Huixi Li2  Lin Wang2  Yu Hui1  Feng Zhou1  | |
[1] Department of Urology, First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, China; E-Mails:;Molecular Biology Laboratory of Andrology Center, Peking University First Hospital, Peking University, Beijing 100034, China; E-Mails: | |
关键词: streptozotocin; spermatogenic dysfunction; IcarisideII; oxidative stress; diabetes mellitus; | |
DOI : 10.3390/ijms150916100 | |
来源: mdpi | |
【 摘 要 】
The aim of this study was to investigate the effects of IcarisideII(ICAII) on the prevention of streptozotocin (STZ) induced spermatogenic dysfunction. Forty male Sprague-Dawley rats received intraperitoneal injection of STZ (55 mg/kg) and were equally randomized to gavage feeding of vehicle (the vehicle group) or ICAII (0.5, 1.5 or 4.5 mg/kg/day, respectively). Ten normal rats received vehicle and served as control. Four weeks later, sperm parameters, histopathological changes, testicular lipid peroxidation, antioxidant enzyme activities, and apoptosis index (AI) were evaluated. Results showed that ICAII treatment resulted in a significant recovery of sperm parameters and histopathological changes relative to the vehicle group (
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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