期刊论文详细信息
Journal of Functional Biomaterials
A Novel Multi-Phosphonate Surface Treatment of Titanium Dental Implants: A Study in Sheep
Marcella von Salis-Soglio2  Stefan St࿋inger2  Michéle Sidler2  Karina Klein2  Stephen J. Ferguson1  Käthi Kämpf2  Katalin Zlinszky2  Sabrina Buchini3  Richard Curno3  Péter Pຜhy3  Bjorn-Owe Aronsson3 
[1] Institute for Biomechanics, ETH Zürich, Vladimir-Prelog-Weg 1-5/10, Zürich 8093, Switzerland; E-Mail:;Musculoskeletal Research Unit, Equine Hospital, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, Zürich 8057, Switzerland; E-Mails:;Nano Bridging Molecules SA, Rte Cité Ouest 2, Gland 1196, Switzerland; E-Mails:
关键词: surface treatment;    multi-phosphonate;    bone formation;    removal torque test;    bone-to-implant-contact;    scanning electron microscopy;    osseointegration;   
DOI  :  10.3390/jfb5030135
来源: mdpi
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【 摘 要 】

The aim of the present study was to evaluate a new multi-phosphonate surface treatment (SurfLink®) in an unloaded sheep model. Treated implants were compared to control implants in terms of bone to implant contact (BIC), bone formation, and biomechanical stability. The study used two types of implants (rough or machined surface finish) each with either the multi-phosphonate Wet or Dry treatment or no treatment (control) for a total of six groups. Animals were sacrificed after 2, 8, and 52 weeks. No adverse events were observed at any time point. At two weeks, removal torque showed significantly higher values for the multi-phosphonate treated rough surface (+32% and +29%, Dry and Wet, respectively) compared to rough control. At 52 weeks, a significantly higher removal torque was observed for the multi-phosphonate treated machined surfaces (+37% and 23%, Dry and Wet, respectively). The multi-phosphonate treated groups showed a positive tendency for higher BIC with time and increased new-old bone ratio at eight weeks. SEM images revealed greater amounts of organic materials on the multi-phosphonate treated compared to control implants, with the bone fracture (from the torque test) appearing within the bone rather than at the bone to implant interface as it occurred for control implants.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.

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